منابع مشابه
A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.
Otitis media (OM), inflammation of the middle ear, is the most common cause of hearing impairment and surgery in children. Recurrent and chronic forms of OM are known to have a strong genetic component, but nothing is known of the underlying genes involved in the human population. We have previously identified a novel semi-dominant mouse mutant, Jeff, in which the heterozygotes develop chronic ...
متن کاملF-box protein substrate recognition
Ubiquitin E3 ligases represent an increasingly diverse group of proteins whose precise biologic role still remains enigmatic. Of the SCF (Skp1-Cullin1-F-box) E3 ligase family, for example, only very few subunits from over 60 family members are well-characterized. The SCF apparatus contains a multi-subunit catalytic core consisting of Skp1, Cullin1 and the E2 ubiquitin-conjugating (Ubc) enzyme a...
متن کاملAn endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana
ARGONAUTE1 (AGO1) mediates microRNA- and small interfering RNA-directed posttranscriptional gene silencing in Arabidopsis thaliana. Mutant alleles of SQUINT (SQN) slightly reduce AGO1 activity and have weak effects on shoot morphology. A screen for mutations that suppress the sqn phenotype produced loss-of-function mutations in the F-box gene FBW2. Mutations in FBW2 not only suppress sqn but al...
متن کاملF-box proteins: the key to protein degradation.
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub to targeted substrates. A major type of E3 Ub ligases, the SCF (Skp-Cullin-F-box) complex, is composed of four major componen...
متن کاملF-Box Protein FBX92 Affects Leaf Size in Arabidopsis thaliana
F-box proteins are part of one of the largest families of regulatory proteins that play important roles in protein degradation. In plants, F-box proteins are functionally very diverse, and only a small subset has been characterized in detail. Here, we identified a novel F-box protein FBX92 as a repressor of leaf growth in Arabidopsis. Overexpression of AtFBX92 resulted in plants with smaller le...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2017
ISSN: 1768-3262
DOI: 10.4267/2042/62321